The Role of Dyslipidemia on Early and Late Onset Preeclampsia

Presenter: Shirley Ivonne Moningkey, Tangerang District General Hospital

Background: Dyslipidemia was found in preeclampsia, but the images are inconsistent, and the classification used is also varied as mild and severe, early onset and late onset preeclampsia. Because early and late onset preeclampsia considered as two different disorders, this study aims to compare the levels of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides in early and late onset preeclampsia.

Methodology: A nested case control study was conducted for 82 normotensive pregnant women, 31 early onset and 31 late onsets pre-eclampsia women. Cases and controls were selected among delivering patients at Tangerang District Hospital between February 2011 and January 2012. Preeclampsia was diagnosed per NHLBI criteria. Blood samples were collected after a 12-hour fast. Samples were immediately centrifuged and processed using a diagnostic kit to determine serum levels of triglycerides, total cholesterol, LDL, HDL and VLDL.

Results: Cholesterol levels (mean ± SD in mg / dl) in normal pregnancies 216.97 ± 52.70 mg / dl, early onset preeclampsia 244.38 ± 54.06, and late onset preeclampsia 211.22 ± 53.29; HDL in normal pregnancy 48.06 ± 12.60,  early onset  preeclampsia  49.51 ± 14:56, late onset preeclampsia 42.46 ± 12:06; LDL in normal pregnancies 126.47 ± 42.11, early onset preeclampsia, 93 ± 44.88 and in late onset 119.79 ± 36.13; triglyceride levels in normal pregnancies 213.70 ± 70.66, early onset 113.9 ± 273.90 and in late onset  259.73 ± 95.03 preeclampsia. Triglyceride is a risk factor of both early and late onset preeclampsia.

Conclusions: Elevated triglycerides, total cholesterol and LDL are present in early onset preeclampsia compared with late onset which supports that there are differences in early and late onset preeclampsia.  Elevated triglyceride is a risk factor of both early and late onset preeclampsia.